Shortcuts
Ctrl+K, C - Comment selected blockCtrl+K, U - Un-comment selected block
Ctrl+K, X - Insert snippet (or tab after snippet name)
Ctrl+K, S - Surround with snippet (or tab after snippet name)
Ctrl+K, M - Insert stub for a new method

Ctrl+Shift+R - Record temp macro
Ctrl+Shift+P - Play temp macro

Ctrl+X - cuts line if no selection
Ctrl+Shift+V - Cycle thru clipboard history

Ctrl+I - Incremental search
Ctrl+G - Goto line number
Ctrl+Shift+F - Find in all files
Ctrl-W - Select current word
Ctrl+PgUp & Ctrl+PgDn Toggle between Aspx Design View and and HTML View

F9 - insert/remove a breakpoint
F12 - Go To Definition

See:
http://www.codinghorror.com/blog/archives/000315.html
http://blogs.msdn.com/shaykatc/archive/2004/03/04/83993.aspx
http://www.dev102.com/2008/04/17/10-visual-studio-shortcuts-you-must-know/
http://www.dev102.com/2008/05/06/11-more-visual-studio-shortcuts-you-should-know/
http://blogs.msdn.com/SaraFord/

Settings
Tools>Options>Environment>Fonts and Colors>Preprocessor Keyword -> Red foreground
Tools>Options>Environment>Fonts and Colors>Brace Matching (Rectangle) -> Silver
Tools>Options>Text Editor>All Languages>Line Numbers ticked
Tools>Options>Environment>Keyboard> Make Tools.RecordTemporaryMacro assigned to Ctrl+Shift+R

Add Custom Commands
View > Navigate Forwards & Backwards
 

VS.NET Extensions
PowerCommands for Visual Studio 2008: http://code.msdn.microsoft.com/PowerCommands
VS2008 Web Deployment System Projects

Reg settings for ".Net Cmd Prompt Here" on right click.

REGEDIT4

[HKEY_LOCAL_MACHINE\SOFTWARE\Classes\Directory\shell\cmdHere]
@=".Net Cmd &Prompt Here"
[HKEY_LOCAL_MACHINE\SOFTWARE\Classes\Directory\shell\cmdHere\command]
@="cmd.exe /k \"C:\\Program Files\\Microsoft Visual Studio 9.0\\Common7\\Tools\\vsvars32.bat\""

[HKEY_LOCAL_MACHINE\SOFTWARE\Classes\Drive\shell\cmdHere]
@=".Net Cmd &Prompt Here"
[HKEY_LOCAL_MACHINE\SOFTWARE\Classes\Drive\shell\cmdHere\command]
@="cmd.exe /k \"C:\\Program Files\\Microsoft Visual Studio 9.0\\Common7\\Tools\\vsvars32.bat\""
 

Explorer Cmd Here (.NET).reg (522.00 bytes)